Winning More Hands vs More Money

Regarding multiple-deck DAS basic strategy:

It is my understanding that some basic strategy suggestions
cause you to lose more hands in certain situations but win
the most money. I believe many of the soft total double-downs
fall into this category. I don't know about splits.

And that is my question for those of you who know this off the
top of your head.

Just for the sake of curiosity ... If one is interested "strictly"
in winning the most number of hands, when does one NOT follow
basic strategy suggestions?

Thanks in advance!