First base the best?

Isn't it true that first base is the best spot on the table because your betting efficiency is more important than any slight alterations you might make to basic strategy? Particularly in a 2 or 4 deck game.
If the running count is +5 in a 2 deck game with one deck left to play and you make your bigger bet if you're at third base and 5 high cards come out before you get your first card your bigger bet is now out there when you actually have a disadvantage. Of course the opposite could happen but I believe it's significantly less likely. Is this correct?