Not in practice
In theory, you could buy up every ticket combination and be assured of a profit when a rollover makes the jackpot exceed the cost of buying all the tickets. The problem is, you could still end up splitting the jackpot and losing money, so you would have to focus exclusively on very unpopular number combinations to keep the operation positive EV, which means you will not be able to cover all the numbers and risk losing millions. An Australian lottery syndicate actually did this and made money.
With Powerball, I think many people buy random number combinations which would probably make it impossible to get an edge, as even unpopular combinations may be selected when they would not be if people had to choose the numbers. In addition, there may be some prohibition on bulk-buying (lottery companies don't like syndicates since this reduces the value of the jackpot for ordinary folk). Even then you have the massive difficulty involved in processing all those tickets. And then you have factors like taxation and so on.
You could just buy a few tickets and have a small positive EV. But the variance is so massive that makes no real sense on any level. It might just be possible to get a valid edge on lotteries where the rollover cash trickles down to the lower prize tiers-even that is rather unlikely, and I don't think any US state lottery has an appropriately equitable distribution of payouts.